DUBAI, United Arab Emirates (AP) — The U.S. and Israel launched a major attack on Iran on Saturday, and President Donald Trump urged the Iranian public to “seize control of your destiny”

by rising up against the Islamic leadership that has ruled the nation since 1979.

Iran retaliated by firing missiles and drones toward Israel and U.S. military bases in the region, and exchanges of fire continued into the evening.

Some of the first strikes on Iran appeared to hit near the offices of Supreme Leader Ayatollah Ali Khamenei. Smoke rose from the capital as part of strikes that Iranian media said occurred nationwide. It wasn’t immediately clear whether the 86-year-old leader was in his offices when the attack occurred.

Iranian Foreign Minister Abbas Araghchi told NBC News that Khamenei and President Masoud Pezeshkian are alive “as far as I know,” and called the attack “unprovoked, illegal and absolutely illegitimate.”